Inhibition of ethanol oxidation by com pounds that inhibit adh, cyp2e1, and catalase results in an increase in the nonoxidative metabolism of alcohol and increased production of faees in the liver and pancreas werner et al. Ethanol, in the context of transportation, is a biofuel at the present primary derived from corn, but can also be produced from sugar cane, soybeans, and other plant material. The influence of ethanol on the metabolism of livers from fed and starved rats has been studied in liverperfusion experiments. Men and women generally have similar alcohol elimination rates when results are expressed as g per hr or g per liter liver volume. Since women have smaller body size and therefore smaller lean body mass, ethanol elimination per unit lean body mass is higher in women. Protein extraction method for the proteomic study of. Animal cells primarily hepatocytes contain cytosolic adh which oxidizes ethanol to acetaldehyde. Aberrant lipin1 contributes to the abnormalities in lipid metabolism associated with afld in rodents and in humans. Pdf pharmacokinetics of ethanol issues of forensic. Ethanol, an alcohol found in nature and in alcoholic drinks, is metabolized through a complex catabolic metabolic pathway. Oxidative and nonoxidative pathways of alcohol metabolism are interrelated. In humans, several enzymes are involved in processing ethanol first into acetaldehyde and further into acetic acid and acetylcoa.
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